Benjamin Vincent,Luke Whitesell,Susan L. Lindquist,Willmen Youngsaye,Stephen L. Buchwald,Jean-Baptiste Langlois,Partha P. Nag,Amal Ting,Barbara J. Morgan,Benito Munoz,Sivaraman Dandapani,Bruce Tidor,R
申请号：
US14430308
公开号：
US09738610B2
申请日:
2013.09.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be a Candida species, Aspergillus species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds.
