Whitehead Institute for Biomedical Research;Massachusetts Institute of Technology;The Broad Institute, Inc.
发明人:
Benjamin Vincent,Luke Whitesell,Susan L. Lindquist,Willmen Youngsaye,Stephen L. Buchwald,Jean-Baptiste Langlois,Jun Pu,Benito Munoz,Sivaraman Dandapani
申请号：
US14435790
公开号：
US09944607B2
申请日:
2013.10.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrate, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive Compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoan, or inhibiting the growth of a fungus or protozoan. The fungus may be a Candida species, Sacchawmyces species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan mitochondrial phosphate carrier protein.
