ERASMUS UNIVERSITY MEDICAL CENTER;ROGER KINGDON CRAIG
发明人:
FRANKLIN GERARDUS GROSVELD,RICHARD WILHELM JANSSENS,MARINUS JOHANNES VAN HAPEREN,ROGER KINGDON CRAIG,ERNIE DE BOER
申请号：
US14211130
公开号：
US20140356907A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
