METHOD AND DEVICE FOR PREDICTING AN EFFECTIVE DOSE OR SUSCEPTIBILITY TO 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE, A METHOD FOR DETERMINING AMOUNT OF XANTHOSINE MONOPHOSPHATE, AND ALSO AN AGENT AND METHOD FOR TREATING MYELODYSPLASTIC SYNDROME
MURASE Motokhiko,MATSUSITA Minako,KOMATSU Kensuke,VATANABE Kumiko,KUVATA Yusuke,TAKEO Atsusi,YAMASITA Rio
申请号：
RU20160127534
公开号：
RU2672872(C2)
申请日:
2015.01.09
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to a method for predicting an effective dose of 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof for a patient with myelodysplastic syndrome. Invention also relates to a method for predicting the susceptibility of said patient to treatment with 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof. In addition, the invention relates to a method for determining the amount of xanthosine monophosphate in whole blood for use in the methods of the invention. Among other things, the invention relates to a kit for predicting an effective dose of 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof for said patient; and a kit for predicting the susceptibility of said patient to treatment with 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
