Jason Brown,Willow Diluzio,Irving H. Fox,Vaithianathan Palaniappan,Catherine Scholz,Nobel T. Truong,Csanad M. Varga
申请号：
US16208294
公开号：
US20190231878A1
申请日:
2018.12.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
