They are useful for treating mammals by dependence on addiction substances, for example addiction to a dopamine producing agent such as cocaine, morphine, amphetamines, nicotine, and / or alcohol. Pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula (1) and methods for the use of the compounds of formula (1) in the treatment of the addition to a dopamine producing agent are also described. Claim 1: A compound of formula (1) wherein: R¹ is hydrogen, optionally substituted C₁₋₆ alkyl, -CH₂OH, -CH₂OP (O) (OR²⁰) (OR²¹),-C (O) Ror -SO₂R²³；R² is hydrogen, optionally substituted C₁₋₆ alkyl, cycloalkyl, or halo； each of R³,R830808,R83099,R8310,R8313,R830404,R1,R2 and R1 3 are independent hydrogen, hydroxy op (o) (or 2 83044) (or 2),-CH OH -CH OP (O) (OR) (OR)optionally substituted alkyl, optionally substituted alkylene, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclyl, aminocarbonyl, acyl (acylamino, -O C₁₋₆ alkyl) -O- (C₁₋₆ alkyl),Ciano, halo, so83222； No. 83088； No. ro 83090； No. ro 83099； No；R⁷ is hydrogen or optionally substituted C₁₋₆ alkyl； each of R²⁰ and R²¹ is independently Na⁺,Li 8314,,Ka. Hydrogen, c83321218c31832626；o R y R pueden combinarse para representar un cati n divalente nico Zn8314 people killedor Mg²⁺；2. Each square kilometer and cubic centimeter is independent of alternative asphalt, alternative epoxy, alternative cyclopropyl, alternative arilo, o-nr-8308； - 83099；and each of R²⁴ and R²⁵ is independently selected from hydrogen or C₁₋₆ alkyl or when combined together with the nitrogen to which they are attached form a heterocycle； or its salt, ester, single stereoisomer, mixture of stereoisomers, or pharmaceutically acceptable tautomer.Son útiles para tratar mamíferos por la dependencia a sust
