用於治療成癮之化合物农业专利-农业专业知识服务系统

发明人:: CANNIZZARO, CARINA E.,坎妮沙罗　卡莉娜,坎妮沙羅　卡莉娜,GRAUPE, MICHAEL,葛罗　麦可,葛羅　麥可,GUERRERO, JUAN A.,桂烈罗　尤安,桂烈羅　尤安,LU, YAFAN,陆亚凡,陸亞凡,STRICKLEY, ROBERT G.,史脆克利　罗伯特,史脆克利　羅伯特,VENKATARAMANI, CHANDRASEKAR,凡卡塔拉马尼　香德拉塞卡,凡卡,坎妮沙罗卡莉娜,坎妮沙羅卡莉娜,葛罗麦可,葛羅麥可,桂烈罗尤安,桂烈羅尤安,史脆克利罗伯特,史脆克利羅伯特,凡卡塔拉马尼香德拉塞卡

摘要：: Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.本發明揭露具有式(I)之結構的新穎化合物：其可用於治療哺乳動物對成癮物質之依賴性，例如對多巴胺生成劑(諸如可卡因、嗎啡、安非他命、尼古丁和/或酒精)成癮。本發明亦揭露包含治療上有效量之式(I)化合物的醫藥組成物及使用式(I)化合物治療對多巴胺生成劑成癮的方法。