THE PRESENT INVENTION PROVIDES PEPTIDES AT LEAST PARTLY DERIVABLE FROM FVIII WHICH ARE CAPABLE OF BINDING TO AN MHC CLASS II MOLECULE WITHOUT FURTHER ANTIGEN PROCESSING AND BEING RECOGNISED BY A FACTOR VIII SPECIFIC T CELL. IN PARTICULAR, THE PRESENT INVENTION PROVIDES A PEPTIDE COMPRISING OR CONSISTING OF THE SEQUENCE EDNIMVTFRNQASR. THE PRESENT INVENTION ALSO RELATES TO THE USE OF SUCH A PEPTIDE FOR THE PREVENTION OR SUPPRESSION OF INHIBITOR ANTIBODY FORMATION IN HAEMOPHILIA A AND/OR ACQUIRED HAEMOPHILIA.
