Crystalline solid form of salt of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, preparation Process and usage
The present invention provides a compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1, useful in the treatment of cancer. It relates to new crystalline solid forms of salts of 1-dicarboxamide and solvates including hydrates thereof. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, and methods of their use for the treatment of cancer, particularly renal cell carcinoma (RCC) and medullary thyroid carcinoma (MTC). To be done. [Selection diagram] None本発明は、がんの治療に有用な、化合物Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－Ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の新規結晶性固体形態、及びそれらの水和物を始めとする溶媒和物に関する。上記結晶性固体形態を含む医薬組成物及び上記結晶性固体形態の製造プロセス、ならびにがん、特に腎細胞癌（ＲＣＣ）及び甲状腺髄様癌（ＭＴＣ）の治療のためのそれらの使用方法も開示される。【選択図】なし
