PULÉ, MARTIN,MEKKAOUI, LEILA,AMROLIA, PERSIS,GHORASHIAN, SARA,KRAMER, ANNE,CHEUNG, GORDON
申请号：
PL16709529
公开号：
PL3265490T3
申请日:
2016.03.04
申请国别(地区):
PL
年份:
2019
代理人:
摘要：
There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1)； CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3)； and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4)； CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
