包含CD19結合域的嵌合抗原受體(CAR)

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专利权人:

发明人:

申请号：

HK18101662.5

公开号：

HK1242341A

申请日:

2018.02.01

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1 – GYAFSSS (SEQ ID No. 1)； CDR2 – YPGDED (SEQ ID No. 2) CDR3 – SLLYGDYLDY (SEQ ID No. 3)； and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1 – SASSSVSYMH (SEQ ID No. 4)； CDR2 – DTSKLAS (SEQ ID No. 5) CDR3 – QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

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中国工程科技知识中心

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http://www.ckcest.cn/home/