Espiroindolina Derivatives of formula (i), wherein R1 is Halogen, hydrous, etc. R2 R3 is Halogen, hydrous, etc. X is Halogen, hydrous, etc. is 0,1 or 2.Preferred compounds are: cyclopropyl - 1 - [2 - (4-fluorophenyl) sulfonyl] - N - [3 - 5 - fluoro - (trifluoromethyl) pyridin-2-yl] methyl} - (, 3, 5 , 6 - hexahidroespiro Indo tiopirano 3,4 - [] - 5 - carboxamide (1, 1 - dioxide n - {[2 - Chloro - 5 - (trifluoromethyl) pyridin-2-yl] methyl} - 2 - 2-cyclopropyl-1 - [1 - (4-fluorophenyl) sulfon Il - 1,2,2] , 3, 5 , 6 - hexahidroespiro [3,4 - tiopirano] indole - 5 - carboxamide, among others.Also relates to processes for their Preparation and Pharmaceutical compositions thereof, and their use for the treatment of diseases associated with sex hormones in both men and WomenDerivados de espiroindolina de formula (I), donde R1 es halogeno, hidrox, etc. R2 es halogeno, hidrox, etc. R3 es halogeno, hidrox, etc. X es 0,1 o 2. Los compuestos preferidos son: 2-ciclopropil-1-[(4-fluorofenil)sulfonil]-N-{[3-fluoro-5- (trifluorometil)piridin-2-il]metil}-1,2,2,3,5,6-hexahidroespiro[indo-3,4-tiopirano]-5-carboxamida,1,1-dioxido N-{[3-cloro-5-(trifluorometil) piridin-2-il]metil}-2- ciclopropil-1-[(4- fluorofenil) sulfonil]-1,2,2,3,5,6-hexahidroespiro[indol-3,4-tiopirano]-5-carboxamida, entre otros. Se refiere tambien a procesos para su preparacion y composiciones farmaceuticas con los mismos, su uso para el tratamiento de enfermedades relacionadas con las hormonas sexuales, tanto en hombres como en mujeres
