DELPHINE GAUFRETEAU,JEAN PLANCHER,THORSTEN MARC - MUSER,THEODOR STOLL,ROLAND HUMM,SABINE KOLCZEWSKI,HANS HILPERT
申请号：
ARP150102019
公开号：
AR100979A1
申请日:
2015.06.24
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
1. This document refers to 2-oxo-2, 3-dihydro-indoles (1) in general formula,a. AR1 is phenyl, or a heteromorphic group composed of 5 or 6 elements, which contains 1, 2 or 3 heteromorphic atoms selected from n, s or O. n heteroatoms in the heteromorphic group can be oxidized to n 8314； - (o 8315)；R1 is a lower hydrocarbon, halogen, cyanogen or cyclopentadiene selected from n, s or O. it is a heteromorphic group composed of 5 or 6 elements, including 1, 2, 3 or 4 heteroatoms. N heteroatoms in the heteromorphic group can be oxidized to n 8314； - (or 8315；)；or is benzo [b] thiophenyl, R² is hydrogen, lower alkyl, cyano halogen, lower alkyl substituted with hydroxyl, lower alkyl substituted with halogen, lower alkyl substituted with amino, lower alkyl substituted with alkoxy, lower alkyl substituted with amide, or is cycloalkyl, X is CH or N, n is 1 or 2, m is 1 or 2, as well as a pharmaceutically acceptable salt thereof, with a racemic mixture, or with its corresponding enantiomer and / or optical isomer and / or stereoisomer . The compounds can be used in the treatment of SNA diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse,Alcoholism and drug addiction, obsessive-compulsive disorder, cognitive disorder, bipolar disorder, emotional disorder, depression, anti treatment depression, anxiety disorder, Alzheimer's disease, autism, Parkinson's disease, chronic pain, extreme personality disorder, Neurodegenerative diseases, sleep disorders, chronic fatigue, stiffness, inflammation, asthma, Huntington's disease, tdah, Ames transverse sclerosis, epilepsy, arthritis effects, autoimmune diseases, virus and bone infections, cardiovascular diseases,Ophthalmic diseases, retinal inflammation and balance problems.La presente se refiere a 2-oxo-2,3-dihidro-indoles de fórmula general (1), en la que: Ar¹ es fenilo o un grupo heteroarilo de cinco o seis elementos, que contiene uno, dos o tres heteroátomos seleccionados de entre N, S ó O,
