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Piperazino [1,2-a] indole - 3 - onas and [1,4] diazepino [1,2-a] indole - 1 - ona as STIMULATORS of NSC
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
JUERGEN WICHMANN,ROLAND JAKOB-ROETNE,RAVI JAGASIA
申请号:
ARP140101448
公开号:
AR095970A1
申请日:
2014.04.01
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Compounds of the General formula (1), in which: r u00b9 is lower alkyl, halogen, alkoxy alkyl substituted by Halogen, Lower, Lower, Lower alkoxy substituted by Halogen or cyano; R u00b2 is Hydrogen or lower alkyl, cf u2083; r u00b3 is Hydrogen, Lower alkyl, alquenilo below Lquinilo heterocicloalquilo Lower, Lower alkyl, cyano substituted, cyano,BENZYL substituted by halogen - 6 - 2 - oxa, AZA spiro [3.3] hept-3-ene - 6-yl or lower alkoxy substituted by Halogen or ch u2082; X is - - - - - ch u2082 ch u2082; or a pharmaceutically acceptable acid Addition Salt, a racemic mixture and / or its enantiomer and its Optical Isomers.The compounds can be used for the treatment of schizophrenia, obsessive-compulsive Personality Disorder, major depression, bipolar disorder, Anxiety Disorders, normal Aging, retinal degeneration, Epilepsy, Traumatic Brain Injury, L Spinal Cord Injury, post-traumatic Stress Disorder, Panic Disorder,Parkinson's disease, dementia, Alzheimer's disease, Cognitive imbalance moderate Cognitive dysfunction induced by chemotherapy, Down Syndrome, Autism Spectrum Disorders, hearing loss, palpitation, spinocerebellar ataxia, sclerosis Amyotrophic lateral's, multiple sclerosis, Huntington disease, strokeDisorders due to radiation therapy, Chronic stress, abuse of Neuroactive Drugs, including alcohol, opiates or Cocaine, methamphetamine, Phencyclidine. It also provides a method for obtaining it.Compuestos de la fórmula general (1), en la que: R¹ es halógeno, alquilo inferior, alcoxi inferior, alquilo inferior sustituido por halógeno, alcoxi inferior sustituido por halógeno o ciano; R² es hidrógeno, CF₃ o alquilo inferior; R³ es hidrógeno, alquilo inferior, alquenilo inferior, alquinilo inferior, heterocicloalquilo, alquilo inferior sustituido por ciano, ciano, bencilo sustituido por halógeno, 2-oxa-6-aza-espiro[3.3]hept-6-ilo o es alcoxi inferior sustituido por halógeno; X es -CH₂- o -CH₂-CH₂-; o a una sal de adición de ácido farmacéuticamente aceptable, a un
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