MASAHIRO OKUYAMA,NADINE NOEL,REMY LUTHRINGER,SANDRA WERNER
申请号：
BR112017011555
公开号：
BR112017011555A2
申请日:
2015.11.30
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention provides a novel polymorph of the compound (I): 2 - ((1- (2- (4-Fluorophenyl) -2-oxo-ethyl) piperidin-4-yl) methyl) isoindolinecarboxylic acid monohydrochloride dihydrate. 1-one, that is, the form (a) of compound (i)? Ho? 2h 2o. Pharmaceutical compositions comprising form (a) of compound (i) -h-2h2o and related methods of treatment are also disclosed.a presente invenção fornece um novo polimorfo do composto (i): di-hidrato de monocloridrato de 2-((1-(2-(4-fluorofenil)-2-oxo-etil)piperidin-4-il)metil)isoindolin-1-ona, isto é, a forma (a) do composto (i)?ho?2h2o. composições farmacêuticas que compreendem a forma (a) do composto (i)?ho?2h2o e métodos relacionados de tratamento são também revelados.
