It refers to a common formula of indolin-2-ona derivative, in which a is phenyl, or an abiotic group composed of five or six members and one or two N atoms, and amida-c (o) - nr1r2 can be added from the group together with two adjacent carbon atoms to form a concentrated ring； R1 / R2 is independent of each other, i.e. hydrogen, Low tar, etc.； R3 is hydrogen or low tar, etc. 1. The preferred compound is 4 - (3,3-dimethyl-6 - (2-methylpyridine-5-il) - 2-oxindorin-1-il) - N, n-dimethylpyridine-2-carboxamida；4 - (3,3-dimethyl-6 - (2-methylpyridine-5-il) - 2-oxindorin-1-il) - n-methylpyridine-2-aminomethylamine. These compounds inhibit l-687414-induced hyperactivity and are useful in the treatment of harmful substances associated with positive and negative symptoms of schizophrenia.Se refiere a derivados de indolin-2-ona de formula general en donde A es fenilo o un grupo heteroarilo de 5 o 6 miembros que contiene uno o dos atomos de N, el grupo amida -C(O)-NR1R2 puede formar junto con dos atomos de carbono colindantes a partir del grupo A un anillo condensado adicional； R1/R2 son independientes el uno del otro, hidrogeno, alquilo inferior, entre otros； R3 es hidrogeno o alquilo inferior, entre otros. Son compuestos preferidos 4-(3,3-dimetil-6-(2-metilpirimidin-5-il)-2-oxoindolin-1-il)-N,N-dimetilpirimidin-2-carboxamida； 4-(3,3-dimetil-6-(2-metilpirimidin-5-il)-2-oxoindolin-1-il)-N-metilpirimidin-2-carboxamida. Dichos compuestos inhiben la hiperlocomocion inducida por L-687,414 y es util en el tratamiento de enfermedades del SNC relacionadas con sintomas positivos (psicosis) y negativos de la esquizofrenia.
