FORMAS SOLIDAS DE (R)-1(2,2-DIFLUOROBENZO[D] [1,3]DIOXOL-5-IL)-N-( 1-(2,3-DIHIDROXIPROPIL)-6-FLUORO-2-(1-HIDROXI-2-METILPROPAN-2-IL) -1H-INDOL-5-IL) CICLOPROPANOCARBOXAMIDA.
YUEGANG ZHANG,BEILI ZHANG,MARIUSZ KRAWIEC,ELAINE CHUNGMIN LEE,ALI KESHAVARZ-SHOKRI,TIM EDWARD ALCACIO
申请号：
MX2012011062
公开号：
MX347804B
申请日:
2011.03.25
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-d ihydroxypropyl)-6-fluoro-2-(1-hydroxy-2- methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.La presente invención se relaciona con las formas sólidas de (r)-1-(2,2-difluorobanzo (d) (1,3) dioxol-5il)-N-(1- (2, 3- dihidroxipropil)-6-fluoro-2-(1-hidroxi-2metilpropan-2-il)-1H-indo l-5il) ciclopancarboxamida (compuesto 1) en forma sustancialmente cristalina (Forma A) o forma amorfa, composiciones farmacéuticas de estas, y métodos de tratamiento con estos.
