THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VYBYL HOLDINGS, INC.
发明人:
ROLOFF, ALEXANDER,GIANNESCHI, NATHAN C.,CALLMANN, CASSANDRA E.,THOMPSON, MATTHEW P.,BERTIN, PAUL A.
申请号：
CA3057292
公开号：
CA3057292A1
申请日:
2018.03.21
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure generally provides nucleotide-based compounds useful for treating various diseases, including cancer. In some aspects, the disclosure provides oligonucleotides that are chemically modified to include an engineered fatty-acid residue, for example, to assist with improving the half-life of such compounds or assisting with cell penetration (e.g., penetration into tumor cells). In some aspects, the disclosure provides compositions that include such modified nucleotides and a protein, such as albumin or mimetics thereof. The disclosure provides various uses of the compounds and compositions.
