The Regents of the University of California;Vybyl Holdings. Inc.
发明人:
Nathan C Gianneschi,Paul A. Bertin
申请号：
US16492656
公开号：
US20200048198A1
申请日:
2018.03.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule histone deacetylase inhibitors (HDIs) that are chemically modified to have one or more moieties that include hydrophobic portions. In some aspects, the disclosure provides compositions that include such modified HDIs and a protein, such as albumin or albumin mimetics. Further, the disclosure provides various uses of these compounds and compositions.
