The Regents of the University of California;Vybyl Holdings, inc.
发明人:
Alexander Roloff,Nathan C. Gianneschi,Cassandra E. Callmann,Matthew P, Thompson,Paul A. Bertin
申请号：
US16492642
公开号：
US20200046846A1
申请日:
2018.03.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure generally provides nucleotide-based compounds useful for treating various diseases, including cancer. In some aspects, the disclosure provides oligonucleotides that are chemically modified to include an engineered fatty-acid residue, for example, to assist with improving the half-life of such compounds or assisting with cell penetration (e.g., penetration into tumor cells). In some aspects, the disclosure provides compositions that include such modified nucleotides and a protein, such as albumin or mimetics thereof. The disclosure provides various uses of the compounds and compositions.
