Jeffrey I. Zink,Bastian Ruehle,Marcus A. Horwitz,Daniel L. Clemens,Bai-Yu Lee Clemens
申请号：
US16389715
公开号：
US20190321486A1
申请日:
2019.04.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed； a cargo disposed in the pores； one or more antigens attached to the surface of the nanoparticle； an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.
