1. This instruction refers to the treatment of acne and other skin infections caused or contributed by acne, Gardnerella vagina or Staphylococcus aureus with toxic oxazolidinox antibiotic compound in a patient. Requirement 1: a method of treating, preventing or reducing skin infection of patients caused or facilitated by leukocyte, gardnerla or Staphylococcus aureus, The method comprises the effective management of a compound from a surface having formula (1) or a tautometer, salt, ester or a medicament acceptable to the same medicament,a. From the group consisting of: phenyl, pyridine, pyridyl, pyridyl and pyridan； B from the group consisting of phenyl, pyridyl, pyridyl and pyridan； het-ch-22833-r3 from the group consisting of the residue of the formula group (2)；M is selected from the group consisting of: a) saturated, unsaturated, or aromatic C₃₋₁₄ carbocycle, and b) saturated, unsaturated, or aromatic 3-14 membered heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen , oxygen, and sulfur, wherein a) or b) is optionally substituted with one or more R⁵ groups；M-L was selected from a group consisting of (a) M-X, (b) M-L 1.c) M-L -X d) M-X-Le) M-L -X-Lf) M-X-L -X-Lg) M-L -X-L -X h) M-X-X-i) M-L -X-X-j) M-X-X-Ly k) M-L -X-X-LIn which X is independently selected from the following groups at each occurrence:(b) No. 830808-c) -N (O) -d) -N (OR) -e) -S (O) -f) -SO NR -(g) 8308； 1832222；(h) 830808-n =,i) 3DN-NR -j) -O-N 3Dk) 3DN-O-(I) =Nm) 3DN-(n) 83088 - 83088；(o) No. 830888； (c) orp) -OC (O) NR -(q) 8308； (c) 830808；(r) 83080； (c) 830808；(s) The remaining formula (3)；L¹ is selected from the group consisting of: a) C₁₋₆ alkyl,b) alquenilo C(c) C83223 asphalt；(a) - (c) any one that may be replaced by one or more r83099 panels may be selected；and L² is selected from the group consisting of: a) C₁₋₆ alkyl,b) alquenilo C(c) C83223 asphalt；(a) - (c) any one that may be replaced by one or more r83099 panels may be selected；R1,In each ca
