Jeremiah, Fiona,Ohlmeyer, Michael,Napier, Susan Elizabeth,Jurgen, Schulz,Jokiel, Patrick,Ratcliffe, Paul David,Letourneau, Jeffrey,Ho, Koc-Kan,McArthur, Duncan Robert
申请号：
AU2007296634
公开号：
AU2007296634B2
申请日:
2007.09.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to a quinazolinone or isoquinolinone derivativeof formula I, wherein R is Calkyl, Ccycloalkyl,CcycloalkylCalkyl, Calkenyl, Calkynyl,said Calkyl, Ccycloalkyl and CcycloalkylCalkylbeing optionally substituted with hydroxy, Calkyloxy, cyanoor one or more halogens； R is Caryl optionally substitutedwith one to three substituents selected from halogen, hydroxy, cyano, Calkyl,Ccycloalkyl, Calkyloxy and Ccycloalkyloxy,said Calkyl, C cycloalkyl, C alkyloxyand CCycloalkyloxy being optionally substituted with one or morehalogens； or R is a 5-10 membered heteroaryl ring system comprisinga heteroatom selected from N, O and S and optionally substituted with a substituentselected from methyl, Calkyloxy and halogen； or R isCcycloalkyl； R is an optional substituent selectedfrom Calkyl, Calkyloxy and halogen, said Calkyland Calkyloxy being optionally substituted with one or more halogens；R is a group located at the 6- or 7- position of the quinazolinone orisoquinolinone ring having the formula Il, wherein R together withone of R forms a 4-8 membered saturated or unsaturated heterocyclicring optionally comprising a further heteroatomic moiety selected from O, Sand NR, said heterocyclic ring being optionally substituted withone or two substituents selected from methyl, halogen, hydroxy and oxo or Rtogether with one of R and R forms a 6-8 membered heterocyclicring optionally substituted with one or two substituents selected from methyl,halogen, hydroxy and oxo； Each R is independently H, halogen or Calkyloptionally substituted with halogen or SOCH or one ofR together with R forms a 4-8 membered saturated or unsaturatedheterocyclic ring optionally comprising a further heteroatomic moiety selectedfrom O, S and NR, said heterocyclic ring being optionally substitutedwith one or two substituents selected from methyl, halogen, hydroxy and oxo；R
