Froestl, Wolfgang,Sreenivasachary, Nampally,Lohmann, Sophie,Lopez Deber, Maria Pilar,Muhs, Andreas,Pihlgren Bosch, Maria
申请号：
ES09164401
公开号：
ES2587014T3
申请日:
2007.11.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound having the general formula (IIa) or (IIb) ** Formula ** in which p is 2 or 3； each linker K is independently C1-3 alkylene which is optionally substituted with one or more C1-4 alkyl groups； the heterocyclic ring B is optionally substituted with one or more substituents selected from C 1-4 alkyl, C 1-4 alkoxy, mono- and di-C 1-4 alkylamino, C 3-7 cycloalkylamino and saturated 5- or 6-membered heterocyclyl, or two substituents they can be joined to form a saturated, unsaturated or aromatic ring of 5 to 7 members that condenses with the heterocyclic ring B； R 1 is selected from -H, -halogen, -C 1-4 alkyl, NH 2, -NH-C 1-4 alkyl, -C 1-4 alkyl-NH 2, -C 1-4 alkyl-NH-C 1-4 alkyl, -aryl, -aryl-R3, -C1-4 alkarylaryl, -C1-4-R3 alkylenearyl, -heteroaryl, heteroaryl-R3, -NH-C 1-4 alkylenearyl, -NH-C 1-4 alkylenearyl, -OH and -O- C1-4 alkyl； and R3 is C1-4 alkyl, halogen, OH or O-C1-4 alkyl； R2 is -H, -C 1-4 alkyl, -aryl or a group of the formulas (IIIa) or (IIIb) ** Formula ** wherein in the formulas (IIIa) and (IIIb): the heterocyclic ring B is optionally substituted with one or more substituents selected from C 1-4 alkyl, C 1-4 alkoxy, mono- and C 1-4 alkylamino, C 3-7 cycloalkylamino and saturated 5- or 6-membered heterocyclyl, or two substituents can be attached to form a ring saturated, unsaturated or aromatic 5 to 7 members that condenses with the heterocyclic ring B； each linker K is independently C1-3 alkylene which is optionally substituted with one or more C1-4 alkyl groups； R1 is selected from -H, -halogen, -C 1-4 alkyl, -NH2, -NH-C 1-4 alkyl, -C 1-4 alkyl-NH 2, -C 1-4 alkylene-C 1-4 alkyl, -aryl, - aryl-R3, -C1-4alkylenearyl, -C1-4-R3 alkylenearyl, -heteroaryl, -heteroaryl-R3, -NH-C1-4alkylenearyl, -NH-C1-4-R3-alkylenearyl, -OH and -O- C1-4 alkyl； q is 0 or 1； and r is 0 or 1.Un compuesto que tiene la fórmula general (IIa) o (IIb)**Fórmula** en la que p es 2 o 3； cada enlazador K es independientemente alquileno C1-3 que está opcionalmente sustituido con u
