David Gerard Bourke,Xianyong Bu,Christopher John Burns,Anthony Nicholas Cuzzupe,John Thomas Feutrill,Tracy Leah Nero,Beata Maria Blannin,Jun Zeng,Shaun Patrick Gaynor
申请号：
US13861344
公开号：
US09040549B2
申请日:
2013.04.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants； hyperproliferative diseases including cancer and myeloproliferative diseases； viral diseases； metabolic diseases and vascular diseases.
