The present invention relates to the benzamide compounds of formula (I) or its pharmaceutically acceptable salts or its prodrug forms, wherein R1 is the pyrazole ring of C- connection, is optionally selected from following group by one or more and replaces: 4 alkyl of C1,4 cycloalkyloxy of 4 naphthenic base of C3,4 alkoxy of C1 and C3. The invention further relates to the preparation method of these compounds, the Pharmaceutical composition containing these compounds and they in preparation preventing or treating the purposes in the drug for being used as antiproliferative agents in tumour or other proliferative disorders, the proliferative disorders are to inhibition of histone deacetylase (HDAC) sensitivity.本發明涉及式(I)的苯甲酰胺化合物或其藥學上可接受的鹽或其前藥形式，其中R1是C-連接的吡唑環，其任選被一或多個選自下列的基團取代：C1 4烷基、C3 4環烷基、C1 4烷氧基和C3 4環烷氧基。本發明還涉及這些化合物的製備方法、含有這些化合物的藥用組合物以及它們在製備在預防或治療腫瘤或其它增殖性病症中用作抗增殖藥的藥物中的用途，所述增殖性病症對抑制組蛋白脫乙酰酶(HDAC)敏感。
