The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy； or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).本發明係關於式(I)之苯甲醯胺化合物：式(I)化合物：其中R1係C－連結之吡唑環，其可選擇性地經一或多個基團取代，此基團係選自C1－4烷基、C3－4環烷基、C1－4烷氧基及C3－4環烷氧基；或其醫藥可接受之鹽或前藥形式。本發明亦係關於製備此等化合物之方法，其醫藥組合物，以及其在製造藥物之用途，以作為抗增殖劑而預防或治療腫瘤或其他增殖性病況，該等病況係對組蛋白脫乙醯基酶(HDAC)之抑制具敏感性者。
