composite particle and process for preparing a composite particle

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专利权人:

NEW JERSEY INSTITUTE OF TECHNOLOGY

发明人:

Catharina Knieke,Daniel To,Ecevit A. Bilgili,Mohammed A. Azad,Rajesh Dave

申请号：

BR112015010704

公开号：

BR112015010704A2

申请日:

2013.11.08

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “composite particle” and process for preparing a composite particle is a composite particle that includes a core with at least one carrier material； a layer of fluidising material on the core surface and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix forming material. One process of manufacturing the composite particles includes the steps of coating the dry catalyst particles with a fluidizing material； preparing a nanoparticle suspension of an ingestible material distributed in a matrix forming material and coating the carrier particles in the fluid bed with the suspension. The process and products provide rapidly dissolving composite particles which can be used for the release of poorly water-soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents agglomeration of particles during the manufacture of composite particles to enable the rapid release and redispersion of nanoparticles from ingestible material. from a dosage form.1 / 1 resumo “partã�cula compã“sita, e, processo para preparar uma partã�cula compã“sitaâ€� uma partã­cula compã³sita que inclui um nãºcleo com pelo menos um material carreador； uma camada de material fluidizante na superfã­cie do nãºcleo e uma camada externa que compreende nanopartã­culas de um material ingerã­vel distribuã­das em pelo menos um material formador de matriz. um processo de fabricar as partã­culas de compã³sito inclui as etapas de revestir as partã­culas de catalisador a seco com um material fluidizante； preparar uma suspensã£o de nanopartã­culas de um material ingerã­vel distribuã­da em um material formador de matriz e revestir as partã­culas de carreador no leito de fluido com a suspensã£o. o processo e os produtos fornecem partã­culas de compã³sito de dissoluã§ã£o rã¡pida que podem ser usados para a liberaã§ã£o de materiais ingerã­veis deficientemente solãºveis em ã¡gua em formas de dosagem adequadas. o processo

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中国工程科技知识中心

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