LING, ISTVAN,ANTONI, FERENE,LEVAY, GYORGY,HARSING, LASZLO,BARKOCZY, JOZSEF,GACSALYI, ISTVAN,SPEDDING, MICHAEL
申请号：
PE0002422012
公开号：
PE16822012A1
申请日:
2012.02.22
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to compounds of formula (i) wherein: R1 is H or an alkyl group (c1-4) is a linear or branched alkyl group R2 (c1-4) linear or branched and R3 is an aryl or heteroaryl Group.Preferred compounds are: 5 - (4 - fluoro - 1 - 2 - benzotien - il) - 8 - methyl - 1.9 - dihydro - 2H - [1,3] oxazolo [4,5] H [2,3] - benzodiazepines - 2 - One 8 - methyl - 5 - (6 - 1.9 - dihydro - quinolinil) - 2H - [1,3] oxazolo [4,5] [- h] 2,3 benzodiazepines - 2 - One among others. Also referred to as a preparation method and a Pharmaceutical composition.These compounds decrease the effects of the neurotransmitter GABA to be useful for the treatment of Alzheimers disease, Schizophrenia, unipolar Depression, Generalized anxietySE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 ES H O UN GRUPO ALQUILO (C1-4) LINEAL O RAMIFICADO R2 ES UN GRUPO ALQUILO (C1-4) LINEAL O RAMIFICADO Y R3 ES UN GRUPO ARILO O HETEROARILO. SON COMPUESTOS PREFERIDOS: 5-(4-FLUORO-1-BENZOTIEN-2-IL)-8-METIL-1,9-DIHIDRO-2H-[1,3]OXAZOLO[4,5-h][2,3]-BENZODIAZEPIN-2-ONA 8-METIL-5-(6-QUINOLINIL)-1,9-DIHIDRO-2H-[1,3]OXAZOLO[4,5-h][2,3]BENZODIAZEPIN-2-ONA ENTRE OTROS. REFERIDO ADEMAS A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS DISMINUYEN LOS EFECTOS DEL NEUROTRANSMISOR GABA SIENDO UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ESQUIZOFRENIA, DEPRESION UNIPOLAR, ANSIEDAD GENERALIZADA
