KEHLER, Jan,RASMUSSEN, Lars Kyhn,LANGGÅRD, Morten,JESSING, Mikkel,VITAL, Paulo Jorge Vieira,JUHL, Karsten,MARIGO, Mauro
申请号：
PE2019001294
公开号：
PE20191323A1
申请日:
2017.12.20
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
A compound of formula I and an acceptable formula salt, wherein: Y1 = n-r1, y2 = C and Y3 = C, or Y1 = c-r1, y2 = n and Y3 = C； Z1 is selected from NH, CH2,O and s, Z2 are selected from NH, CH2,R1 is hydrogen, C1-4 linear or branched tar, C3-4 saturated monocyclic gas, which can be replaced by one or more halides； R2 is C1-6 linear or branched tar, C3-6 saturated monocyclic gas, oxetanil, tetrahydrofuran and tetrahydropyridine, which can be replaced by one or more halogens； R3 is a heteromorphic compound composed of 5 or 6 members, which can be replaced by one or more alternatives selected from C1-4 linear or branched tar； R4 is a heteromorphic compound composed of 5 or 6 members. 1. The preferred compound is 6 - (2-etoxi-3-piridil) - 3-isoprotil-1-met-n - [(1-methylimidazol-4-il) met] pirazolo [3, 4-b] piridin-4-amine；6 - (2-etoxi-3-piridil) - 3-isoprotil-1-met-n - [(2-met oxazol-4-il) met] pirazolo [3, 4-b] piridin-4-amine, etc. These compounds are inhibitors of phosphatase type 1 (pde1),For the treatment of neurodegeneration and psychosis It also refers to the pharmacological synthesis of these compounds.Referido a un compuesto de formula I y sales aceptables del mismo, donde: Y1 = N-R1, Y2 = C e Y3 = C, o Y1 = C-R1, Y2 = N e Y3 = C； Z1 se selecciona de NH, CH2 , O y S； Z2 se selecciona entre NH, CH2 , O y S； R1 es hidrogeno, alquilo C1-4 lineal o ramificado y cicloalquilo C3-4 monociclico saturado, opcionalmente sustituido con uno o mas halogenos； R2 es alquilo C1-6 lineal o ramificado, cicloalquilo C3-6 monociclico saturado, oxetanilo, tetrahidrofuranilo y tetrahidropiranilo, todos opcionalmente sustituidos con uno o mas halogenos； R3 es un heteroarilo de 5 o 6 miembros, que puede estar opcionalmente sustituido con uno o mas sustituyentes seleccionados de alquilo C1-4 lineal o ramificado, entre otros； y R4 es un heteroarilo de 5 o 6 miembros. Son compuestos preferidos: 6-(2-etoxi-3-piridil)-3-isopropil-1-metil-N-[(1-metilimidazol-4-il) metil]pirazolo[3,4-b]piri
