Refers to compounds derived from bis (- 1.4 - benzodiazepinona fluoroalquil) of formula (i) wherein R1 is - or - ch2cf3 ch2ch2cf3 R2 is ch2cf3 ch2ch2cf3 -, - or - ch2ch2ch2cf3 R3 is H or CH3 ra IS F, CL, CN, among others Z is 0 to 2.Preferred compounds are (2R, 3S) - N - ((3S) - 1 - methyl - 2 - oxo - 4 - phenyl - 2,3 Dihydro 1,4 benzodiazepines - 1H - - - 3 - yl) - 2,3-bis () - trifluoropropil) succinamida (2R, 3S) - N - ((3S) - 2 - oxo - 4 - phenyl - 2,3 Dihydro 1,4 benzodiazepines - 1H - - - 3 - yl) - 2,3-bis () - trifluoropropil) succinamida (2R, 3S) - N - ((3S) - 1 - methyl - 2 - oxo - phenyl - 2 - 5, 3 - 1H - 1,4 - dihydro - 4 - benzodiazepine yl) - 2 - (2,2,2 - trifluoroetil) - 3 - (3.33 - trifluoropropil) succinamida among others. It also relates to a Pharmaceutical Composition and a Crystalline form. These compounds are inhibitors of Notch being useful in the treatment of cancerSE REFIERE A COMPUESTOS DERIVADOS DE BIS(FLUOROALQUIL)-1,4-BENZODIAZEPINONA DE FORMULA (I) DONDE R1 ES -CH2CF3 O -CH2CH2CF3 R2 ES -CH2CF3, -CH2CH2CF3 O -CH2CH2CH2CF3 R3 ES H O -CH3 Ra ES F, Cl, -CN, ENTRE OTROS z ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (2R,3S)-N-((3S)-1-METIL-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2,3-BIS(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA (2R,3S)-N-((3S)-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2,3-BIS(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA (2R,3S)-N-((3S)-1-METIL-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2-(2,2,2-TRIFLUOROETIL)-3-(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMA CRISTALINA Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE NOTCH SIENDO UTILES EN EL TRATAMIENTO DE CANCER
