UTILISATION DE RECEPTEURS D'ANTIGENE CHIMERIQUES (CAR) COMPORTANT UN COSTIMULATEUR INDUCTIBLE (ICOS) AFIN D'AMELIORER L'ACTIVITE ANTITUMORALE ET LA PERSISTANCE DES CAR
JUNE, CARL H.,GUEDAN CARRIO, SONIA,ZHAO, YANGBING,SCHOLLER, JOHN
申请号：
CA2864688
公开号：
CA2864688A1
申请日:
2013.02.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Thl7 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.
