USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

JUNE, CARL H.,SCHOLLER, JOHN,POSEY, AVERY, D.

申请号：

SG11201404284S

公开号：

SG11201404284SA

申请日:

2013.02.22

申请国别(地区):

SG

年份:

2014

代理人:

摘要：

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/