USE OF ICOS-BASED CARS TO ENHANCE ANTITUMOR ACTIVITY AND CAR PERSISTENCE

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专利权人:

THE TRUSTEES OF UNIVERSITY OF PENNSYLVANIA

发明人:

JUNE, CARL, H.,GUEDAN CARRIO, SONIA,ZHAO, YANGBING,SCHOLLER, JOHN

申请号：

SG11201404769U

公开号：

SG11201404769UA

申请日:

2013.02.22

申请国别(地区):

SG

年份:

2014

代理人:

摘要：

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/