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5-Fluoruoracil Derivatives
专利权人:
发明人:
申请号:
EP12186564.6
公开号:
EP2712868A1
申请日:
2012.09.28
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to a compound represented by formula (I)wherein X is selected from the group of formulae (II) to (IV)whereinR1 is H or C1-C50 chain which may be branched or linear and which may be saturated or unsaturated and which may optionally be interrupted and/or substituted by one or more hetero atom(s) (Het1) and/or functional group(s)(G1) orR1 is a C3-C28 moiety which comprises at least one cyclic structure and which may be saturated or unsaturated and which may optionally be interrupted and/or substituted by one or more hetero atom(s) (Het1) and functional group(s)(G1)R2 is H orR2 is a Mono-phosphate, Di-phosphate, Tri-phosphate or phosphoramidite moiety orR2 is -Y-X or -Y-L-Y1- XY and Y1 are independently from each other a single bond or a functional connecting moiety,X is a colloid-active compound (CA) or a fluorescence marker (FA) or a polynucleotide moiety having up to 50 nucleotide residues, preferably 10 to 25 nucleotides, especially a polynucleotide having an antisense or antigen effectL is a linker by means of which Y and X are covalently linked togetherR3 and R4 represent independently from each other a C1-C28-alkyl moiety which may optionally be substituted or interrupted by one or more heteroatom(s) and/or functional group(s)orR3 and R4 form a ring having at least 5 members, preferably a ring having 5 to 8 carbon atoms and wherein the ring may be substituted or interrupted by one or more hetero atom(s) and/or functional group(s) orR3 and R4 represent independently from each other a C1-C28-alkyl moiety substituted with one or more moieties selected from the group -Y-X or -Y-L-Y1-X orR3 and R4 represent independently from each other -Y-X or -Y-L-Y1- XR5 and R6 represent independently from each other a C1-C28-alkyl moiety which may optionally be substituted or interrupted by one or more heteroatom(s) and/or functional group(s) orR5 and R6 represent independently from each other a C1-C28-alkyl moiety substituted with one or more moietie
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