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PROCEDE DE TRAITEMENT DE CANCER ET AUTRES CONDITIONS OU ETATS MALADIFS UTILISANT DES ANALOGUES DE NUCLEOSIDE L-CYTOSINE
专利权人:
YALE UNIVERSITY
发明人:
CHENG, YUNG-CHI
申请号:
EP06844526
公开号:
EP1968595A4
申请日:
2006.11.22
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R1 is H, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester group, a (C) or (D) group; Where Nu is a radical of a biologically active compound such as an anticancer, antihyperproliferative or antiviral compound such that an amino group or hydroxyl group from said biologically active agent forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; Each R8 is independently H, or a C1-C20 alkyl or ether group, preferably H or a C1-C2 alkyl group; k is 0-12, preferably, 0-2; R2 is H, an acyl group or a C1-C20 alkyl or ether group; and pharmaceutically acceptable salts, solvates or polymorphs thereof for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states.
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