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DÉRIVÉS DE 5-FLUOROURIDINE
专利权人:
B. Braun Melsungen AG
发明人:
ROSEMEYER, Helmut,MALECKI, Edith
申请号:
EP13770450
公开号:
EP2900679B1
申请日:
2013.09.25
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention relates to a compound represented by formula (I) wherein X is selected from the group of formulae (II) to (IV) wherein R 1 is H or C 1 -C 50 chain which may be branched or linear and which may be saturated or unsaturated and which may optionally be interrupted and/or substituted by one or more hetero atom(s) (Het1) and/or functional group(s)(G1); or R 1 is a C 3 -C 28 moiety which comprises at least one cyclic structure and which may be saturated or unsaturated and which may optionally be interrupted and/or substituted by one or more hetero atom(s) (Het1) and functional group(s)(G1); R 2 is H; or R 2 is a Mono-phosphate, Di-phosphate, Tri-phosphate or phosphoramidite moiety; or R 2 is -Y-X or -Y-L-Y 1 - X; Y and Y 1 are independently from each other a single bond or a functional connecting moiety, X is a colloid-active compound (CA) or a fluorescence marker (FA) or a polynucleotide moiety having up to 50 nucleotide residues, preferably 10 to 25 nucleotides, especially a polynucleotide having an antisense or antigen effect; L is a linker by means of which Y and X are covalently linked together; R 3 and R 4 represent independently from each other a C 1 -C 28 -alkyl moiety which may optionally be substituted or interrupted by one or more heteroatom(s) and/or functional group(s);or R 3 and R 4 form a ring having at least 5 members, preferably a ring having 5 to 8 carbon atoms and wherein the ring may be substituted or interrupted by one or more hetero atom(s) and/or functional group(s); or R 3 and R 4 represent independently from each other a C 1 -C 28 -alkyl moiety substituted with one or more moieties selected from the group -Y-X or -Y-L-Y 1 -X; or R 3 and R 4 represent independently from each other -Y-X or -Y-L-Y 1 - X; R 5 and R 6 represent independently from each other a C 1 -C 28 -alkyl moiety which may optionally be substituted or interrupted by one or more heteroatom(s) and/or functi
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