ROSE, SCOTT,BEHLKE, MARK A.,OWCZARZY, RICHARD,WALDER, JOSEPH A.,THOMAS, DEREK M.,MARVIN, MICHAEL R.
申请号：
EP11760380
公开号：
EP2553123A4
申请日:
2011.03.28
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
A composition comprising an oligonucleotide having the structure 5&prime；-Y1-L1-X-L2-Y2-3&prime；. Y1 comprises a sequence of one or more DNA or RNA nucleotides, including a first nucleotide N1 having a 3&prime； phosphate covalently linked to L1. Y2 comprises a sequence of one or more DNA or RNA nucleotides, including a second nucleotide N2 having a 5&prime； phosphate covalently linked to L2. L1 and L2 each independently are a direct bond or a C1-C7 alkyl, alkynyl, alkenyl, heteroalkyl, substituted alkyl, aryl, heteroaryl, substituted aryl, cycloalkyl, alkylaryl, or alkoxyl group. X is R1 is a hydrogen or a C1-C8 alkyl. M is a label or ligand comprising a fused polycyclic aromatic moiety.
