MACDONALD LYNN,STEVENS SEAN,GURER CAGAN,MURPHY ANDREW J.,MEAGHER KAROLINA A.
申请号：
NZ62721112
公开号：
NZ627211A
申请日:
2012.12.17
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a non-human animal whose genome comprises: (a) an insertion of one or more human V&lambda； gene segments and one or more human J&lambda； gene segments upstream of a non-human immunoglobulin light chain constant region gene, (b) an insertion of one or more human VH gene segments, one or more human DH gene segments and one or more human JH gene segments upstream of a non-human immunoglobulin heavy chain constant region gene, and (c) an ectopic nucleic acid sequence that encodes an ADAM6 protein or a functional fragment thereof, wherein the ADAM6 protein or functional fragment thereof is expressed from the ectopic nucleic acid sequence.
