MACDONALD, Lynn,MCWHIRTHER, John,TU, Naxin,MURPHY, Andrew, J.,STEVENS, Sean
申请号：
DK13710268
公开号：
DK2858487T3
申请日:
2013.03.07
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V<；sub>；H<；/sub>；gene segment, a plurality of human D<；sub>；H<；/sub>；gene segments and a plurality of human J<；sub>；H<；/sub>；gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.
