MACDONALD, Lynn,MCWHIRTHER, John,TU, Naxin,STEVENS, Sean,MURPHY, Andrew J.
申请号：
AU2020202185
公开号：
AU2020202185A1
申请日:
2020.03.27
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020202185A120200416.pdf#####ABSTRACT Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain focus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.
