Eddy Jean Edgard Freyne;Peter Ten Holte;Gaston Stanislas Marcella Diels;Kristof Van Emelen;Thierry Andre Regis Grand-Perret;Pascal Ghislain André Bonnet;Werner Constant Johan Embrechts
发明人:
Gaston Stanislas Marcella Diels,Peter Ten Holte,Eddy Jean Edgard Freyne,Thierry Andre Regis Grand-Perret,Kristof Van Emelen,Werner Constant Johan Embrechts,Pascal Ghislain André Bonnet
申请号：
US12670670
公开号：
US08318731B2
申请日:
2008.07.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.
