Forme amorphe solide de (R)-1(2,2-difluorobenzo(D)(1,3)dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-méthylpropane-2-yl)-1H-indol-5-yl)-cyclopropanecarboxamide

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专利权人:

Vertex Pharmaceuticals Incorporated

发明人:

申请号：

EP14172991.3

公开号：

EP2826776A1

申请日:

2011.03.25

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates to solid amorphous form of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (compound 1), pharmaceutical compositions thereof, solid dispersions thereof and the compound 1 for use in the treatment of a CFRT mediated diseases such as cytosic fibrosis

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