PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY TRANSMEMBRANE CRYSTAL FIBROSIS REGULATOR CFTR

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专利权人:

ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US)

发明人:

ВЕРВЕЙС, Маринус, Якобус (US),КАРКАРЕ, Радхика (US),МУР, Майкл, Дуглас (US)

申请号：

RU2019117882

公开号：

RU2019117882A

申请日:

2013.11.01

申请国别(地区):

RU

年份:

2019

代理人:

摘要：

Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

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