LEEK, Michael David,HANNIGAN, Adele,PATAKAS, Agapitos,PARUZINA, Daria
申请号：
SG11201708401W
公开号：
SG11201708401WA
申请日:
2016.04.14
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The present invention provides the compositions and method for treating cancer or infectious diseases in the mankind. The present invention includes the generation and application of gamma delta T cells, the gamma delta T cells express Chimeric antigen receptor (CAR), and the Chimeric antigen receptor (CAR) includes antigen-binding domains, hinge domain, transmembrane domain, includes or the costimulatory signal conducting structure domain not comprising CD3 ζ signal transduction structural domains. It omits expression of the CAR sequences of CD3 ζ signal transduction structural domains in gamma delta T cells and provides internal CAR-T treatments, the target cell that gamma delta T cells receptor (TCR) will be only activated to ligand is provided generates cell dissolution.
