Michael David Leek,Adele Hannigan,Agapitos Patakas,Daria Paruzina
申请号：
US15566324
公开号：
US20180125889A1
申请日:
2016.04.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).
