LEEK, MICHAEL DAVID,HANNIGAN, ADELE,PATAKAS, AGAPITOS,PARUZINA, DARIA
申请号：
CA2982523
公开号：
CA2982523A1
申请日:
2016.04.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta ? cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).
