Isolated Nucleic Acid Sequence encoding a Chimeric Antigen receptor, which comprises an Antigen binding domain, a transmembrane Domain, a region of coestimulatoria signaling and Signaling domain of CD3 Zeta； receptor； Cell； vector； and its use to treat a A disease related to high expression of a tumor Antigen.
JUNE, CARL, H.,LEVINE, BRUCE, L.,PORTER, DAVID, L.,KALOS, MICHAEL D.,MILONE, MICHAEL, C.
申请号：
CL2013001645
公开号：
CL2013001645A1
申请日:
2013.06.07
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.SECUENCIA DE ACIDO NUCLEICO AISLADA QUE CODIFICA UN RECEPTOR DE ANTIGENO QUIMERICO, EL CUAL COMPRENDE UN DOMINIO DE UNION A ANTIGENO, UN DOMINIO TRANSMEMBRANA, UNA REGION DE SEÑALIZACION COESTIMULATORIA Y UN DOMINIO DE SEÑALIZACION CD3 ZETA； DICHO RECEPTOR； CELULA； VECTOR； Y SU USO PARA TRATAR UNA ENFERMEDAD RELACIONADA CON LA EXPRESION ELEVADA DE UN ANTIGENO TUMORAL.
