PROBLEM TO BE SOLVED: To provide a novel CAR using a solid tumor antigen as a target antigen, and CAR-T cells effective against a solid tumor. A chimeric antigen receptor comprising a target antigen-binding region, a transmembrane region, and a T cell activation signal transduction region, wherein the target antigen is ganglioside GM2. A cell expressing the chimeric antigen receptor. A polynucleotide comprising a nucleotide sequence encoding the chimeric antigen receptor. A vector containing the nucleotide sequence. A method for producing a cell expressing a chimeric antigen receptor, which comprises introducing the polynucleotide or the vector into the cell. A pharmaceutical composition comprising the cells. [Selection diagram] None【課題】固形腫瘍抗原を標的抗原とする新規ＣＡＲ、及び固形腫瘍に対して有効なＣＡＲ－Ｔ細胞の提供。【解決手段】標的抗原結合領域と、膜貫通領域と、Ｔ細胞活性化シグナル伝達領域とを含み、前記標的抗原がガングリオシドＧＭ２である、キメラ抗原受容体。前記キメラ抗原受容体を発現する細胞。前記キメラ抗原受容体をコードする塩基配列を含むポリヌクレオチド。前記塩基配列を含むベクター。前記ポリヌクレオチド又はベクターを細胞に導入することを含む、キメラ抗原受容体を発現する細胞の製造方法。前記細胞を含む医薬組成物。【選択図】なし
