GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS

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专利权人:

BOARD OF REGENTS; THE UNIVERSITY OF TEXAS SYSTEM

发明人:

Laurence J.N. COOPER,Harjeet SINGH,Helen HULS,Simon OLIVARES,Bipulendu JENA,Krina PATEL

申请号：

US15524328

公开号：

US20170333480A1

申请日:

2015.11.05

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.

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中国工程科技知识中心

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http://www.ckcest.cn/home/